1.Check the speaker connections and the volume settings on the speakers.
2.Adjust the E4x4 Pre Line output and headphone amp output volume.
3.Check the settings on the ToppingPro.
4.Connect E4x4 Pre and your computer directly without using a USB hub.
5.Remove the USB devices which are connected with your computer and not in use, and then confirm the sound.
6.Quit all applications you are not using then confirm the sound.